niacin ameliorates lipid disturbances due to glucocorticoid administration in rats

نویسندگان

niloofar safaei division of physiology, department of basic sciences, school of veterinary medicine, shiraz university, shiraz, iran

tahoora shomali division of pharmacology and toxicology, department of basic sciences, school of veterinary medicine, shiraz university, shiraz, iran

mahnaz taherianfard division of physiology, department of basic sciences, school of veterinary medicine, shiraz university, shiraz, iran

چکیده

objective(s) this study was conducted to evaluate the effects of niacin on glucocorticoid-induced dyslipidemia and fatty liver in rats. materials and methods twenty four adult male rats were divided randomly into four equal groups: 1- normal saline (control), 2- dexamathasone 0.125 mg/kg/day, i.m., 3- dexamathasone + niacin 200 mg/kg/day, oral gavages, 4- niacin. after 2 weeks, serum total cholesterol, triglycerides, hdl-c, ldl-c and vldl-c concentrations were assayed and liver sections examined for fatty liver changes. data were analyzed by anova method and         p< 0.05 was considered significant. results dexamethasone increased all lipid parameters as compared to control (p< 0.05). lipid parameters in group 3, were lower than group 2 (p< 0.05) except for hdl-c which remained statistically the same. moderate fatty liver changes were observed in one third of rats in dexamethasone group. rats in groups 1, 3 and 4 had no sign of fatty changes. conclusion niacin positively affects glucocorticoid-induced dyslipidemia and fatty liver changes in rats.

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عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۵، شماره ۴، صفحات ۹۹۷-۱۰۰۲

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